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This is especially critical for plasma donors
Key takeaways from TRIUMPH-4 (68 weeks): 28.7% average weight loss at the highest dose 1 in 4 participants lost 35% of body weight ~76% reduction in knee pain Meaningful improvements in BP and lipid markers This pushes weight-loss outcomes closer to bariatric-surgery territory, while also improving joint pain and cardiometabolic risk
These are modest compared to pharmaceutical options
It works through the carnitine shuttle, moving fatty acids into mitochondria so they can be used for energy
To get the best from both treatments, it's essential to make healthy lifestyle changes alongside them
Although targeting NMDA receptors to reduce weight is not a novel concept, previous attempts have failed due to the side effects associated with systemic inhibition of NMDA receptors, such as hyperthermia and hyperactivity
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